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pentobarbital will reduce the level or effect of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will reduce the extent or result of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Double brexpiprazole dose more than one-two weeks if ad